Chisa Yukizome begins her job as homeroom teacher for Hope's Peak Academy's 77th Class of Ultmate students. Meanwhile, Hajime Hinata, a student of the school's Reserve Course for students without talent, prepares to undergo an experiment to make him the Ultimate Hope. What follows is a series of tragic events which lead to the birth of the Remnants of Despair and the realization of "The Biggest, Most Awful, Most Tragic Event in Human History."

Aired alongside of Danganronpa 3: Mirai-hen, with Mirai-hen starting first.